| November 1, 2021 |
Georgia Southwestern State |
Clemson, SC |
Win
|
77-51 |
|
| November 9, 2021 |
Presbyterian College |
Clemson, SC |
Win
|
64-53 |
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|
| November 12, 2021 |
Wofford |
Clemson, SC |
Win
|
76-68 |
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|
| November 15, 2021 |
Bryant |
Clemson, SC |
Win
|
93-70 |
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|
| November 18, 2021 |
Temple |
Charleston, SC |
Win
|
75-48 |
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|
| November 19, 2021 |
St. Bonaventure |
Charleston, SC |
Loss
|
65-68 |
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|
| November 21, 2021 |
West Virginia |
Charleston, SC |
Loss
|
59-66 |
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|
| November 26, 2021 |
Charleston Southern |
Clemson, SC |
Win
|
91-59 |
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|
| November 30, 2021 |
Rutgers |
Piscataway, NJ |
Loss
|
64-74 |
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|
| December 4, 2021 |
Miami |
Coral Gables, FL |
Loss
|
75-80 |
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|
| December 11, 2021 |
Drake |
Atlanta, GA |
Win
|
90-80 |
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|
| December 14, 2021 |
Miami (OH) |
Clemson, SC |
Win
|
89-76 |
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|
| December 18, 2021 |
South Carolina |
Clemson, SC |
Win
|
70-56 |
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|
| December 22, 2021 |
Virginia |
Charlottesville, VA |
Win
|
67-50 |
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|
| January 4, 2022 |
Virginia |
Clemson, SC |
Loss
|
65-75 |
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|
| January 8, 2022 |
NC State |
Raleigh, NC |
Win
|
70-65 |
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|
| January 12, 2022 |
Notre Dame |
Notre Dame, IN |
Loss
|
56-72 |
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|
| January 15, 2022 |
Boston College |
Clemson, SC |
Loss
|
68-70 |
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|
| January 18, 2022 |
Syracuse |
Syracuse, NY |
Loss
|
78-91 |
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|
| January 22, 2022 |
Pittsburgh |
Clemson, SC |
Win
|
75-48 |
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|
| January 25, 2022 |
Duke |
Durham, NC |
Loss
|
69-71 |
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|
| February 2, 2022 |
Florida State |
Clemson, SC |
Win
|
75-69 |
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|
| February 5, 2022 |
Georgia Tech |
Atlanta, GA |
Loss
|
64-69 |
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|
| February 8, 2022 |
North Carolina |
Clemson, SC |
Loss
|
77-79 |
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|
| February 10, 2022 |
Duke |
Clemson, SC |
Loss
|
82-64 |
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|
| February 12, 2022 |
Notre Dame |
Clemson, SC |
Loss
|
61-76 |
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|
| February 15, 2022 |
Florida State |
Tallahassee, FL |
Loss
|
80-81 |
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|
| February 19, 2022 |
Louisville |
Louisville, KY |
Loss
|
61-70 |
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|
| February 23, 2022 |
Wake Forest |
Clemson, SC |
Win
|
80-69 |
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|
| February 26, 2022 |
Boston College |
Chestnut Hill, MA |
— |
70-60 |
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|
| March 2, 2022 |
Georgia Tech |
Clemson, SC |
Win
|
68-65 |
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|
| March 5, 2022 |
Virginia Tech |
Clemson, SC |
Win
|
63-59 |
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|
| March 8, 2022 |
NC State |
Brooklyn, NY (ACC Tournament) |
Win
|
70-64 |
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|
| March 9, 2022 |
Virginia Tech |
Brooklyn, NY (ACC Tournament) |
Loss
|
75-76 |
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|
