The 1959 Clemson-South Carolina Game

27 - 0 Clemson

For 64 years, Clemson traveled to Columbia to face the Gamecocks for the annual Big Thursday rivalry. This year would mark the end of the tradition as the rivalry progressed to a home-and-home series played on a Saturday. However, the two schools would not move the contest to the last regular season game until two years later. Clemson won the final Big Thursday match-up 27–0.

Source: Wikipedia